Urokinase Antimetastatic Effects—Letter

Urokinase Exerts Antimetastatic Effects by Dissociating Clusters of Circulating Tumor Cells-Letter.

Clusters of circulating tumor cells (CTC) exhibit more robust metastatic properties than single CTC. Thus, understanding the distinct behaviors of CTC clusters and how CTC clustering is regulated may offer new insights into how to limit metastasis. In this study, we utilized an in vivo confocal system to observe the clustering behavior of CTC in real time, finding that the number of clusters in...

Urokinase Exerts Antimetastatic Effects by Dissociating Clusters of Circulating Tumor Cells

Clusters of circulating tumor cells (CTC) exhibit more robust metastatic properties than single CTC. Thus, understanding the distinct behaviors of CTC clusters and how CTC clustering is regulated may offer new insights into how to limit metastasis. In this study, we utilized an in vivo confocal system to observe the clustering behavior of CTC in real time, finding that the number of clusters in...

Meta-tyrosine: Powerful Antimetastatic Factor

Concomitant tumor resistance (CR) is a phenomenon in which a tumor-bearing host is resistant to the growth of secondary tumor implants and metastasis. While former studies have indicated that T-cell dependent processes mediate CR in hosts bearing immunogenic small tumors, the most universal manifestation of CR induced by immunogenic and non-immunogenic large tumors had been associated with an a...

Antitumor and Antimetastatic Activity of

Effective models for antimetastatic therapies

Despite the successful therapeutic regimens for the treatment of primary tumors, effective interventions for metastatic lesions are lacking. Metastasis is a complex process, wherein the cancer cells pass through multifaceted steps from the primary site to establish tumor at the distant site. This multifaceted process begins with the establishment of highly vascularized primary tumor, local inva...